Document! X and HelpStudio Bundle can publish directly to any IIS Web Site that has the Web Deploy service installed and configured.
Web Deploy can be installed on an IIS Server using the Microsoft Web Platform Installer.
You can find more information on installing and configuring Web Deploy here: http://www.iis.net/downloads/microsoft/web-deploy
The Target URL field is the URL at which the content is located once it has been deployed. This setting is not required for successful publishing, but it allows the publishing results to show a convenient link to open the published content once the publishing is complete.
Note: Only specify the root URL and not the landing page - i.e. http://myhost.mydomain.com/ and not http://myhost.mydomain.com/webframe.html.